γ-Butyrolactones from Aspergillus Species: Structures, Biosynthesis, and Biological Activities
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γ-Butyrolactones from Aspergillus Species: Structures, Biosynthesis, and Biological Activities
Nat Prod Commun.
2017 May.
Abstract
Recently, numerous metabolites possessing uncommon structures and potent bioactivity have been isolated from strains of fungi collected from diverse environments. The genus Aspergillus is known as a rich source of y-butyrolactones. These are a group of fungal secondary metabolites, consisting of a five- membered lactone bearing two aromatic rings, which shows a great variety of biological activities. This review summarizes the research on the biosynthesis, source, and biological activities of the naturally occurring y-butyrolactones that have been isolated from Aspergillus species published over the last decades. More than 75 compounds are described and 65 references are cited.
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