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Review
. 2018 Oct;45(5):318-322.
doi: 10.1159/000492629. Epub 2018 Aug 24.

An International Registry of Granulocyte Transfusions

Monica B Pagano  1 , Suzy Morton  2 , Claudia S Cohn  3 , Sylvie Gross  4 , Jose Kutner  5 , Antoine Lewin  6 , Jeffrey McCullough  3 , Irwin Schweitzer  7 , Alan T Tinmouth  8 , Kamille West  9 , Simon J Stanworth  10
Affiliations
Review

An International Registry of Granulocyte Transfusions

Monica B Pagano et al. Transfus Med Hemother. 2018 Oct.

Abstract

Introduction: Granulocyte transfusions are used to either treat or prevent life-threatening infections in neutropenic patients. Current evidence from clinical trials does not support or reject efficacy, nor guide practice.

Methods: A group of investigators have led the efforts to create an online registry to gather information on granulocyte transfusion practices from as broad a range of international settings. The data forms were adapted from an on-going study in England for electronic data management. Data is collected at the time of the request for granulocytes, weekly, at 28 days, and at 6 months. Information collected includes donor, granulocyte unit, patient and illness characteristics, and outcomes.

Results: The PROspective GRanulocyte usage and outcomEs Survey (ProGrES) is currently open for data entry. Centres across the UK have collected data on 80 subjects. Five institutions from 4 countries (2 from the US, 1 each from Brazil, and national services in Canada and France) are in the process of joining the study. Other countries have expressed interest.

Conclusion: It is feasible to develop an international registry of granulocyte transfusions to characterise current practices and describe outcomes. This registry would provide a platform to explore the relationship between intervention and outcomes, and to generate evidence to inform granulocyte transfusion efficacy.

Keywords: Granulocytes; Infection; Neutropenia; Registry.

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