Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2018 Oct 16:5:34.
doi: 10.21037/sci.2018.09.05. eCollection 2018.

Acute myeloid leukemia remodels endosteal vascular niche into a leukemic niche

Bijender Kumar  1   2 , Ching Cheng Chen  1
Affiliations
Editorial

Acute myeloid leukemia remodels endosteal vascular niche into a leukemic niche

Bijender Kumar et al. Stem Cell Investig. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
AML development drives remodeling of endosteal niches resulting in generation of pro-leukemia microenvironments. Drawn based on the results from the original Cell Stem Cell 2018 paper (17). AML, acute myeloid leukemia; LT-HSC, long-term hematopoietic stem cell; BM, bone marrow.
See this image and copyright information in PMC

Comment on

  • Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML.
    Duarte D, Hawkins ED, Akinduro O, Ang H, De Filippo K, Kong IY, Haltalli M, Ruivo N, Straszkowski L, Vervoort SJ, McLean C, Weber TS, Khorshed R, Pirillo C, Wei A, Ramasamy SK, Kusumbe AP, Duffy K, Adams RH, Purton LE, Carlin LM, Lo Celso C. Duarte D, et al. Cell Stem Cell. 2018 Jan 4;22(1):64-77.e6. doi: 10.1016/j.stem.2017.11.006. Epub 2017 Dec 21. Cell Stem Cell. 2018. PMID: 29276143 Free PMC article.

References

    1. Morrison SJ, Scadden DT. The bone marrow niche for haematopoietic stem cells. Nature 2014;505:327-34. 10.1038/nature12984 - DOI - PMC - PubMed
    1. Mendelson A, Frenette PS. Hematopoietic stem cell niche maintenance during homeostasis and regeneration. Nat Med 2014;20:833-46. 10.1038/nm.3647 - DOI - PMC - PubMed
    1. Oudhia P. Positive (inhibitory) allelopathic effects of Parthenium leaves on germination and seedling vigour of sunflower. Crop Research (Hisar) 2000;20:560-2.
    1. Sipkins DA, Wei X, Wu JW, et al. In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment. Nature 2005;435:969-73. 10.1038/nature03703 - DOI - PMC - PubMed
    1. Colmone A, Amorim M, Pontier AL, et al. Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells. Science 2008;322:1861-5. 10.1126/science.1164390 - DOI - PubMed