Late-Stage Peptide Diversification through Cobalt-Catalyzed C-H Activation: Sequential Multicatalysis for Stapled Peptides

Abstract

Bioorthogonal late-stage diversification of structurally complex peptides has enormous potential for drug discovery and molecular imaging. In recent years, transition-metal-catalyzed C-H activation has emerged as an increasingly viable tool for peptide modification. Despite major accomplishments, these strategies largely rely on expensive palladium catalysts. We herein report an unprecedented cobalt(III)-catalyzed peptide C-H activation, which enables the direct C-H functionalization of structurally complex peptides, and sets the stage for a multicatalytic C-H activation/alkene metathesis/hydrogenation strategy for the assembly of novel cyclic peptides.

Keywords: C−H activation; cobalt; cyclopeptides; metathesis; peptides.