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. 2018 Nov 29;175(6):1457-1459.
doi: 10.1016/j.cell.2018.11.020.

Mechanobiology of Protein Droplets: Force Arises from Disorder

Timothy J Welsh  1 , Yi Shen  1 , Aviad Levin  1 , Tuomas P J Knowles  2
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Mechanobiology of Protein Droplets: Force Arises from Disorder

Timothy J Welsh et al. Cell. .
Free article

Abstract

The use of optogenetic approaches has revealed new roles for intracellular protein condensates described in two papers in this issue of Cell (Bracha et. al., 2018; Shin et al., 2018). These results show that growing condensates are able to exert mechanical forces resulting in chromatin rearrangement, establishing a new role for liquid-liquid phase separation in the mechanobiology of the cell.

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