Trained Immunity and Local Innate Immune Memory in the Lung

Abstract

Trained innate immunity mediates protection against heterologous infections and is mediated by epigenetic and functional reprogramming of myeloid cells and their progenitors. Now, Yao et al. describe trained immunity induced locally in alveolar macrophages by a viral infection, with IFNγ release from effector CD8⁺ lymphocytes initiating this process.