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. 2018 Nov 30;2(Suppl 1):42-45.
doi: 10.1182/bloodadvances.2018GS112057.

Managing thalassemia in the developing world: an evidence-based approach for prevention, transfusion independency, and curative treatment with hematopoietic stem cell transplantation

Saqib Hussain Ansari  1 , Sadia Parveen  1 , Saima Siddiqui  1 , Kousar Perveen  1 , Ghazala Ahmed  1 , Bushra Kaleem  1 , Shariq Ahmed  1 , Muhammad Zohaib  1 , Tasneem Farzana  1 , Tahir Shamsi  1
Affiliations

Managing thalassemia in the developing world: an evidence-based approach for prevention, transfusion independency, and curative treatment with hematopoietic stem cell transplantation

Saqib Hussain Ansari et al. Blood Adv. .
No abstract available

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Figures

Figure 1.
Figure 1.
Distribution of different genetic mutations in different provinces. KPK, Karachi, Pakistan.
Figure 2.
Figure 2.
Forty significant metabolites that showed significant differences among healthy individuals and patients with β-thalassemia.
Figure 3.
Figure 3.
Plot of principle components analysis (PCA) scores of healthy individuals and patients with TM.
Figure 4.
Figure 4.
Overall survival among patients with thalassemia on the basis of conditioning regimen.
Figure 5.
Figure 5.
Overall number of transplants in thalassemia patients (n = 153).
See this image and copyright information in PMC

References

    1. Ansari SH, Shamsi TS, Ahmed FN, Perveen K, Ahmed G. Effectiveness and feasibility of transabdominal chorionic villous sampling procedure for prenatal diagnosis of β-thalassaemia in a Muslim majority community of Pakistan. Pak J Med Sci. 2012;28(3):575-579.
    1. Ansari SH, Shamsi TS, Ashraf M, et al. . Molecular epidemiology of β-thalassemia in Pakistan: far reaching implications. Int J Mol Epidemiol Genet. 2011;2(4):403-408. - PMC - PubMed
    1. Ansari SH, Shamsi TS, Siddiqui FJ, et al. . Efficacy of hydroxyurea (HU) in reduction of pack red cell (PRC) transfusion requirement among children having beta-thalassemia major: Karachi HU trial (KHUT). J Pediatr Hematol Oncol. 2007;29(11):743-746. - PubMed
    1. Ansari SH, Shamsi TS, Ashraf M, et al. . Efficacy of hydroxyurea in providing transfusion independence in β-thalassemia. J Pediatr Hematol Oncol. 2011;33(5):339-343. - PubMed
    1. Musharraf SG, Iqbal A, Ansari SH, Parveen S, Khan IA, Siddiqui AJ. β-thalassemia patients revealed a significant change of untargeted metabolites in comparison to healthy individuals. Sci Rep. 2017;7:42249. - PMC - PubMed