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. 2018 Nov 30;8(1):17510.
doi: 10.1038/s41598-018-35552-8.

Comparison of bone texture between normal individuals and patients with Kashin-Beck disease from plain radiographs in knee

Wenrong Li  1   2 , Jukka Hirvasniemi  3 , Xiong Guo  4 , Simo Saarakkala  5   6   7 , Mikko J Lammi  2   8 , Chengjuan Qu  9
Affiliations

Comparison of bone texture between normal individuals and patients with Kashin-Beck disease from plain radiographs in knee

Wenrong Li et al. Sci Rep. .

Abstract

To compare tibial bone texture between Kashin-Beck disease (KBD) patients and normal individuals from plain radiographs using an advanced image analysis. Plain knee radiographs were obtained from KBD patients (n = 49) and age-matched healthy controls (n = 98). KBD were graded with diagnostic criteria WS/T 207-2010. The textural values related to bone structure from medial and lateral tibial subchondral and trabecular bones were evaluated using entropy of Laplacian-based image (ELap), entropy of local binary patterns (ELBP), homogeneity indices (HI) of local angles (HIMean, HIPerp and HIParal), and fractal dimensions from horizontal (FDHor) and vertical (FDVer) structures. KBD patients were shorter in height and lighter in weight, and their tibial width was wider than controls. Anatomical angle of KBD patients showed more genu valgus. Total KBD patients and subgroups had higher ELap, HIMean, HIPerp and HIParal in detected tibial subchondral and trabecular bones than controls, except ELap in lateral subchondral bone. ELBP, FDHor and FDVer from the detected tibial bone in KBD patients and subgroups were lower than controls, except FDVer in lateral trabecular bone. Our results indicate that micro-scale in bone texture in KBD-affected knees can be quantitatively examined from plain radiographs using an advanced image analysis.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Clinical (a) and radiological (b) findings in a 55-year old female with KBD in right knee joint.
Figure 2
Figure 2
Representative mean ± SD and statistical significance of bone structural parameters, entropy of laplacian-based image (Elap) and local binary patterns (ELBP) measured from medial and lateral subchondral and trabecular bone between control healthy individuals (n = 98) and Kashin-Beck disease (KBD, n = 49) patients. *Stands for P < 0.05, **Stands for P ≤ 0.001.
Figure 3
Figure 3
Representative mean ± SD and statistical significance of bone structural parameters, mean of homogeneity index (HIMean) and HI perpendicular (0°, HIPerp) and parallel (90°, HIParal) to the trabecular main orientation, measured from medial and lateral subchondral and trabecular bone between control individuals (n = 98) and Kashin-Beck disease (KBD, n = 49). *Stands for P < 0.05, **Stands for P ≤ 0.001.
Figure 4
Figure 4
Representative mean ± SD and statistical significance of bone structural parameters, fractal dimension of horizontal (FDHor) and vertical structures (FDVer), measured from medial and lateral subchondral and trabecular bone between control individuals (n = 98) and Kashin-Beck disease (KBD, n = 49). *Stands for P < 0.05, **stands for P ≤ 0.001.
Figure 5
Figure 5
Schematic figure of placement ROIs. Two subchondral bone ROIs (93 × 40 pixels, white rectangles) were placed under the cartilage-bone interface in the middle part of medial and lateral condyles of the tibia. Two trabecular bone ROIs (93 × 93 pixels, black rectangles) were placed below and parallel to the subchondral bone ROIs of the tibia. Minimum JSWs (white dotted line) were measured from the narrowest point of the joint from both the medial and the lateral sides. Anatomical angles were medially measured from the intersection of a line from the center of the head of femur to the center of the tibial spines, and a second line from the center of the tibia to the center of the tibial spines.
See this image and copyright information in PMC

References

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