Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Nov 26:23:56.
doi: 10.1186/s11658-018-0121-1. eCollection 2018.

Latent viruses can cause disease by disrupting the competition for the limiting factor p300/CBP

Hanan Polansky  1 , Hava Schwab  1
Affiliations
Review

Latent viruses can cause disease by disrupting the competition for the limiting factor p300/CBP

Hanan Polansky et al. Cell Mol Biol Lett. .

Abstract

CBP and p300 are histone acetyltransferase coactivators that control the transcription of numerous genes in humans, viruses, and other organisms. Although two separate genes encode CBP and p300, they share a 61% sequence identity, and they are often mentioned together as p300/CBP. Zhou et al. showed that under hypoxic conditions, HIF1α and the tumor suppressor p53 compete for binding to the limiting p300/CBP coactivator. Jethanandani & Kramer showed that δEF1 and MYOD genes compete for the limited amount of p300/CBP in the cell. Bhattacharyya et al. showed that the limiting availability of p300/CBP in the cell serves as a checkpoint for HIF1α activity. Here, we use the microcompetition model to explain how latent viruses with a specific viral cis-regulatory element in their promoter/enhancer can disrupt this competition, causing diseases such as cancer, diabetes, atherosclerosis, and obesity.

Keywords: HIF1α, p53, CBP; Limiting; MYOD; Microcompetition; Transcription factor; p300; δEF1.

PubMed Disclaimer

Conflict of interest statement

Not applicableBoth authors consent to the publication of the article.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Latent viruses, the microcompetition model, and disease. a Immunodeficiency occurs due to stress, aging, disease, etc. b More copies of the latent virus are present in the system c Due to the increase in the copies of latent viruses, more GABP•p300/CBP complexes bind the viral promoters. d As a result, fewer GABP•p300/CBP complexes are available to bind the promoter of the cellular gene. e A lower or higher expression of cellular genes. f Disease occurs
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Rual J, Venkatesan K, Hao T, et al. Towards a proteome-scale map of the human protein–protein interaction network. Nature. 2005;437(7062):1173–1178. doi: 10.1038/nature04209. - DOI - PubMed
    1. Kasper L, Fukuyama T, Biesen M, et al. Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development. Mol Cell Biol. 2006;26(3):789–809. doi: 10.1128/mcb.26.3.789-809.2006. - DOI - PMC - PubMed
    1. Kasper L, Brindle P. Mammalian gene expression program resiliency: the roles of multiple coactivator mechanisms in hypoxia–responsive transcription. Cell Cycle. 2005;5(2):142–146. doi: 10.4161/cc.5.2.2353. - DOI - PubMed
    1. Jethanandani P, Kramer R. α7 integrin expression is negatively regulated by δEF1 during skeletal Myogenesis. J Biol Chem. 2005;280(43):36037–36046. doi: 10.1074/jbc.m508698200. - DOI - PubMed
    1. Zhou C, Zhang X, Liu F, Wang W. Modeling the interplay between the HIF-1 and p53 pathways in hypoxia. Sci Rep. 2015;5(1). 10.1038/srep13834. - PMC - PubMed

MeSH terms

Substances