Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2018 Oct;9(5):871-874.
doi: 10.21037/jgo.2018.05.18.

Brain metastasis and herniation in a patient with ampullary adenocarcinoma presenting with jaundice and memory loss: case report

Abdullah Saleh ALQattan  1 , Omar Ali Al-Ghamdi  1 , Mumtaz Sarang  2 , Mohammed Saad Al-Qahtani  3
Affiliations
Case Reports

Brain metastasis and herniation in a patient with ampullary adenocarcinoma presenting with jaundice and memory loss: case report

Abdullah Saleh ALQattan et al. J Gastrointest Oncol. 2018 Oct.

Abstract

Periampullary carcinoma includes neoplasms arising from head of pancreas, distal common bile duct, duodenum and ampulla of Vater. We report a case of a 41-year-old male, medically free who presented to our hospital as a case of obstructive jaundice, weight loss, headache and blurred vision. Clinical evaluation revealed memory loss and ataxia. Endoscopic retrograde cholangiopancreatography (ERCP) was carried out and showed a mass in the ampullary area, histopathology showed ampullary adenocarcinoma. Metastatic work up was carried out which revealed two brain metastatic lesions and multiple intra-abdominal metastasis. We are reporting the third case of brain metastasis from ampullary adenocarcinoma. It metastasizes commonly intra-abdominally, but extra-abdominal metastases are rare yet it should be included in the differential diagnosis of patients with a history of ampullary carcinoma who present with neurological symptoms. There are no current specific management guidelines for brain metastasis secondary to ampullary adenocarcinoma, so general brain metastasis management is applicable.

Keywords: Ampullary; adenocarcinoma; brain; metastasis.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Brain MRI T2.
Figure 2
Figure 2
Brain CT.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Sunil BJ, Seshadri RA, Gouthaman S, et al. Long-Term Outcomes and Prognostic Factors in Periampullary Carcinoma. J Gastrointest Cancer 2017;48:13-9. 10.1007/s12029-016-9863-z - DOI - PubMed
    1. Chavez MT, Sharpe JP, O'Brien T, et al. Management and outcomes following pancreaticoduodenectomy for ampullary adenocarcinoma. Am J Surg 2017;214:856-61. 10.1016/j.amjsurg.2017.01.029 - DOI - PubMed
    1. Pancreatric Section, British Society of Gastroenterology ; Pancreatic Society of Great Britain and Ireland; Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland, et al. Guidelines for the management of patients with pancreatic cancer periampullary and ampullary carcinomas. Gut 2005;54 Suppl 5:v1-16. 10.1136/gut.2004.057059 - DOI - PMC - PubMed
    1. Askew J, Connor S. Review of the investigation and surgical management of resectable ampullary adenocarcinoma. HPB (Oxford) 2013;15:829-38. 10.1111/hpb.12038 - DOI - PMC - PubMed
    1. Voutsadakis IA, Doumas S, Tsapakidis K, et al. Bone and brain metastases from ampullary adenocarcinoma. World J Gastroenterol 2009;15:2665-8. 10.3748/wjg.15.2665 - DOI - PMC - PubMed

Publication types