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Case Reports
. 2018 Nov-Dec;9(6):445-447.
doi: 10.4103/idoj.IDOJ_24_18.

Lamotrigine-induced Systemic Lupus Erythematosus: A Diagnostic Dilemma

Jaskaran Batra  1 , Sukhjot Kaur  1 , Sandeep Kaushal  2 , Aminder Singh  3
Affiliations
Case Reports

Lamotrigine-induced Systemic Lupus Erythematosus: A Diagnostic Dilemma

Jaskaran Batra et al. Indian Dermatol Online J. 2018 Nov-Dec.

Abstract

Many drugs are known to cause systemic lupus erythematosus (SLE), however there are no well defined criteria for drug induced lupus erythematosus (DILE). We present a rare case of lamotrigine induced lupus presenting as acute syndrome of apoptotic pan epidermolysis (ASAP).

Keywords: Acute syndrome of apoptotic pan epidermolysis; Systemic Lupus erythematosus; lamotrigine.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Erythematous maculopapular rash involving the entire face and neck with erosions, crusting, and vesiculation
Figure 2
Figure 2
Diffuse maculopapular erythema on right arm
Figure 3
Figure 3
Periungual erosions and splinter hemorrhage
Figure 4
Figure 4
Basal layer vacuolar degeneration with presence of necrotic keratinocytes and mild superficial perivascular lympho-histiocytic infiltrate [hematoxylin and eosin (H and E 400×)]
Figure 5
Figure 5
Resolution of lesions within 1 week
See this image and copyright information in PMC

References

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