Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Mar;58(1):81-88.
doi: 10.1007/s00411-018-0766-1. Epub 2018 Dec 1.

Immunological status of chronically exposed persons with increased level of TCR mutations

A A Akleyev  1   2 , E A Blinova  3   4 , Ilya I Dolgushin  5
Affiliations

Immunological status of chronically exposed persons with increased level of TCR mutations

A A Akleyev et al. Radiat Environ Biophys. 2019 Mar.

Abstract

Dose- and dose rate-dependent increase in the number of СD3+СD16+CD56+-lymphocytes and lysosomal activity of neutrophils was noted in peripheral blood of the Techa riverside residents with increased level of TCR gene-mutated T lymphocytes long after chronic exposure of predominantly red bone marrow (mean exposure dose was 0.89 ± 0.09 Gy, individual dose range was 0.09-1.96 Gy). The performed analysis showed that the above-mentioned immunological changes could be a response to an increase in the frequency of mutations (TCR mutations in particular) in the cells of exposed individuals.

Keywords: Chronic exposure; Immunological status; Red bone marrow; TCR mutations.

PubMed Disclaimer

References

    1. Trends Immunol. 2003 Feb;24(2):82-7 - PubMed
    1. Radiats Biol Radioecol. 2002 Nov-Dec;42(6):624-7 - PubMed
    1. Health Phys. 2012 Jul;103(1):58-60 - PubMed
    1. J Immunol Methods. 2000 Sep 21;243(1-2):167-90 - PubMed
    1. Radiat Res. 2003 May;159(5):581-96 - PubMed

Publication types

Substances

LinkOut - more resources