Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2019 Feb;597(3):673-675.
doi: 10.1113/JP277386. Epub 2018 Dec 11.

Transient downregulation of BDNF is required for GABAergic maturation in rat primary visual cortex

Matthew J Buchan  1
Affiliations
Comment

Transient downregulation of BDNF is required for GABAergic maturation in rat primary visual cortex

Matthew J Buchan. J Physiol. 2019 Feb.
No abstract available

Keywords: Development; GABA, BDNF; Visual cortex.

PubMed Disclaimer

Figures

Figure 1
Figure 1. A period of synaptic imbalance exists in the normal development of rat V1
Enhanced inhibition relative to excitation was observed between P28 and P33/34 as measured by spontaneous excitatory postsynaptic currents, and the increased amplitude and frequency of spontaneous inhibitory postsynaptic currents in layer 5 pyramidal neurons. Additionally, the ratio of excitation to inhibition was seen to decrease significantly during this period as measured by evoked postsynaptic currents.
See this image and copyright information in PMC

Comment on

References

    1. Aid T, Kazantseva A, Piirsoo M, Palm K & Timmusk T (2007). Mouse and rat BDNF gene structure and expression revisited. J Neurosci Res 85, 525–535. - PMC - PubMed
    1. Liu Q & Wong‐Riley MTT (2013). Postnatal development of brain‐derived neurotrophic factor (BDNF) and tyrosine protein kinas (TrkB) receptor immunoreactivity in multiple brainstem respiratory nuclei of the rat. J Comp Neurol 521, 109–129. - PMC - PubMed
    1. Mizohuchi Y, Ishibashi H & Nabekura J (2003). The action of BDNF on GABAA currents changes from potentiating to suppressing during maturation of rat hippocampal CA1 pyramidal neurons. J Physiol 548, 703–709. - PMC - PubMed
    1. Nair B & Wong‐Riley MTT (2016). Transcriptional regulation of brain‐derived neurotrophic factor coding exon IX: Role of nuclear respiratory factor 2. J Biol Chem 291, 22583–22593. - PMC - PubMed
    1. Tuncdemir SN, Wamsley B, Stam FJ, Osakada F, Goulding M, Callaway EM, Rudy B & Fishell G (2016). Early somatostatin interneuron connectivity mediates the maturation of deep layer cortical circuits. Neuron 89, 521–535. - PMC - PubMed

Substances

LinkOut - more resources