Spinal direct current stimulation (tsDCS) in hereditary spastic paraplegias (HSP): A sham-controlled crossover study

Abstract

Objective: Hereditary spastic paraplegia (HSP) represents a heterogeneous group of neurodegenerative diseases characterized by progressive spasticity and lower limb weakness. We assessed the effects of transcutaneous spinal direct current stimulation (tsDCS) in HSP.Design: A double-blind, randomized, crossover and sham-controlled study.Setting: Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milan.Participants: eleven patients with HSP (six men, mean age ± SD: 37.3 ± 8.1 years), eight affected by spastin/SPG4,1 by atlastin1/SPG3a, 1 by paraplegin/SPG7 and 1 by ZFYVE26/SPG15.Interventions: tsDCS (anodal or sham, 2.0 mA, 20', five days) delivered over the thoracic spinal cord (T10-T12).Outcome measures: Motor-evoked potentials (MEPs), the H-reflex (Hr), F-waves, the Ashworth scale for clinical spasticity, the Five Minutes Walking test and the Spastic Paraplegia Rating Scale (SPRS) were assessed. Patients were evaluated before tsDCS (T₀), at the end of the stimulation (T₁), after one week (T₂), one month (T₃) and two months (T₄).Results: The score of the Ashworth scale improved in the anodal compared with sham group, up to two months following the end of stimulation (T₁, P = .0137; T₄, P = .0244), whereas the Five Minutes Walking test and SPRS did not differ between the two groups. Among neurophysiological measures, both anodal and sham tsDCS left Hr, F-waves and MEPs unchanged over time.Conclusions: Anodal tsDCS significantly decreases spasticity and might be a complementary strategy for the treatment of spasticity in HSP.

Keywords: Hereditary spastic paraplegias; Movement disorders; Non-invasive spinal stimulation; Spasticity treatment; Transcutaneous spinal direct current stimulation.

Figure 1

Ashworth scale for lower limbs and sub-items. Anodal tsDCS (white circles) significantly reduced total Ashworth score compared with sham stimulation (black squares), at T₁ and T₄; this improvement with respect to hip flexion and knee extension (left and right, bottom row). The data are expressed as mean values ± S.E. (*P< .05; **P< .01).