Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Oct 11;16(19):9299-306.
doi: 10.1093/nar/16.19.9299.

Mutational study of the rRNA in yeast mitochondria: functional importance of T1696 in the large rRNA gene

B Daignan-Fornier  1 , M Bolotin-Fukuhara
Affiliations
Free PMC article

Mutational study of the rRNA in yeast mitochondria: functional importance of T1696 in the large rRNA gene

B Daignan-Fornier et al. Nucleic Acids Res. .
Free PMC article

Abstract

Four intragenic suppressors of a mitochondrial mutation in the 21S rRNA gene have been characterized in S. cerevisiae. The determination of the nature of the nucleotide changes in the suppressor strains showed that a T at position 1696 in the large rRNA gene is essential for correct function of the mitoribosome. The importance of this specific nucleotide and the fact that this mitochondrial mutation can also be suppressed by a mutation in a nuclear gene are in good agreement with a rRNA-r protein interaction in this part of domain IV, which functional importance is demonstrated in vivo by our results.

PubMed Disclaimer

References

    1. Nucleic Acids Res. 1983 Jan 25;11(2):339-48 - PubMed
    1. Nucleic Acids Res. 1982 Aug 11;10(15):4795-801 - PubMed
    1. Nucleic Acids Res. 1983 Nov 25;11(22):7795-817 - PubMed
    1. Nucleic Acids Res. 1983 Nov 25;11(22):7819-31 - PubMed
    1. Mol Gen Genet. 1984;193(2):280-7 - PubMed

Publication types