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. 2018 Dec 3;18(1):110.
doi: 10.1186/s12894-018-0416-6.

Abiraterone acetate for chemotherapy-naive metastatic castration-resistant prostate cancer: a single-centre prospective study of efficacy, safety, and prognostic factors

Liancheng Fan  1 , Baijun Dong  1 , Chenfei Chi  1 , Yanqing Wang  1 , Yiming Gong  1 , Jianjun Sha  1 , Jiahua Pan  1 , Xun Shangguan  1 , Yiran Huang  1 , Lixin Zhou  2 , Wei Xue  3
Affiliations

Abiraterone acetate for chemotherapy-naive metastatic castration-resistant prostate cancer: a single-centre prospective study of efficacy, safety, and prognostic factors

Liancheng Fan et al. BMC Urol. .

Abstract

Background: To evaluate the efficacy and safety of abiraterone acetate (AA) plus prednisone compared with prednisone alone in Asian patients with chemotherapy-naive metastatic castration-resistant prostate cancer (mCRPC), and to identify predictive factors.

Methods: We reviewed the medical records of 60 patients with chemotherapy-naive mCRPC at Renji Hospital who were treated with AA plus prednisone (n = 43) or prednisone alone (n = 17). All patients were assessed for prostate-specific antigen (PSA) response, PSA progression-free survival (PSA PFS), radiographic progression-free survival (rPFS), and overall survival (OS). The ability of several parameters to predict PSA PFS, rPFS, and OS was studied.

Results: The median follow-up time was 14.0 months (range 7.0-18.5 months), at which time 19 death events had been reported: 11 in the AA + prednisone group and 8 in the prednisone group. The AA + prednisone group had significantly longer median PSA PFS (10.3 vs 3.0 months, P < 0.001), rPFS (13.9 vs 3.9 months, P < 0.001), and OS (23.3 vs 17.5 months, P = 0.016) than the prednisone-alone group. The most frequently reported grade 3 or 4 adverse event in both the AA + prednisone and prednisone-alone groups was elevated alanine aminotransferase level in 5 of 43 patients (11.6%) and 2 of 17 patients (11.8%), respectively. No adverse events led to discontinuation of therapy. In multivariate analysis, time from androgen deprivation therapy (ADT) to castration resistance of ≤18 months was a determinant of shorter OS (P = 0.007).

Conclusions: These results support the favourable safety and efficacy profile of AA for the treatment of Asian patients with chemotherapy-naive mCRPC. Longer duration of ADT response was significantly associated with longer survival.

Keywords: Abiraterone; Chemotherapy-naive; Metastatic castration-resistant prostate cancer; Response to previous therapy.

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Conflict of interest statement

Competing interest

The authors declare that they have no competing interests.

Ethics approval and consent to participate

Approval for this study was obtained from the Committee for Ethics of Renji Hospital. Sixty patients with chemotherapy-naive mCRPC provided informed consent and were enrolled in our study.

Consent for publication

Yes.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
mCRPC patients in the AA + prednisone group had significantly longer survivals than those in prednisone group
Fig. 2
Fig. 2
Receiver operating characteristic curve analysis of the optimal cut-off for the time from ADT to castration resistance
See this image and copyright information in PMC

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