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Comment
. 2018 Dec;24(12):978-981.
doi: 10.1016/j.molmed.2018.10.002. Epub 2018 Oct 24.

Novel Approach to Tracking Mutant Huntingtin in Biosamples

Katarina Trajkovic  1 , Dimitri Krainc  2
Affiliations
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Novel Approach to Tracking Mutant Huntingtin in Biosamples

Katarina Trajkovic et al. Trends Mol Med. 2018 Dec.

Abstract

Although the established causative agent in Huntington's disease (HD) is a mutation in a single gene encoding huntingtin protein, the pathogenic cascade preceding neuronal death and disease onset is both incompletely understood and clinically undetectable. A new article published in Molecular Cell explores mutant huntingtin (mHtt) aggregate seeding activity as an early pathogenesis-tracking parameter with potential biomarker quality.

Keywords: Huntington’s disease; biomarker; mutant huntingtin; seeding aggregation.

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