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. 1988 Mar;64(749):193-5.
doi: 10.1136/pgmj.64.749.193.

Effects of captopril in patients with chronic obstructive pulmonary disease and secondary pulmonary hypertension

D Patakas  1 , D Georgopoulos, H Rodini, P Christaki
Affiliations

Effects of captopril in patients with chronic obstructive pulmonary disease and secondary pulmonary hypertension

D Patakas et al. Postgrad Med J. 1988 Mar.

Abstract

Ten patients with chronic obstructive pulmonary disease (COPD) with normal left ventricular function were given a single dose of captopril (0.25 mg/kg). Mean systemic arterial pressure, heart rate and coronary flow to the right ventricle were reduced significantly after captopril. In contrast captopril did not cause a significant fall in pulmonary arterial pressure or pulmonary vascular resistance. We conclude that captopril fails to produce haemodynamic benefits in such hypoxic patients and that angiotensin II is not playing a significant role in maintaining pulmonary vasoconstriction.

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