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. 1988 Oct;85(19):7069-73.
doi: 10.1073/pnas.85.19.7069.

The B- to Z-DNA equilibrium in vivo is perturbed by biological processes

W Zacharias  1 , A Jaworski, J E Larson, R D Wells
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The B- to Z-DNA equilibrium in vivo is perturbed by biological processes

W Zacharias et al. Proc Natl Acad Sci U S A. 1988 Oct.

Abstract

Right-handed B and left-handed Z conformations coexist in equilibrium in portions of plasmids in Escherichia coli. The equilibria are influenced by the length of the sequences that undergo the structural transitions and are perturbed by biological processes. The composite results of three types of determinations indicate a supercoil density of -0.025 in vivo. The coexistence of alternative DNA conformations in living cells implies the potential of these structures or their transitions for important functions in genetic regulatory processes.

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References

    1. J Biol Chem. 1982 Sep 10;257(17):10159-65 - PubMed
    1. Prog Nucleic Acid Res Mol Biol. 1980;24:167-267 - PubMed
    1. Anal Biochem. 1982 May 15;122(2):253-7 - PubMed
    1. Nature. 1983 Apr 14;302(5909):632-4 - PubMed
    1. Proc Natl Acad Sci U S A. 1983 May;80(9):2447-51 - PubMed

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