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Comment
. 2018 Dec;8(12):1515-1517.
doi: 10.1158/2159-8290.CD-18-1143.

TET2 Deficiency Sets the Stage for B-cell Lymphoma

Jennifer R Shingleton  1 , Sandeep S Dave  2
Affiliations
Comment

TET2 Deficiency Sets the Stage for B-cell Lymphoma

Jennifer R Shingleton et al. Cancer Discov. 2018 Dec.

Abstract

TET2 is a well-established tumor suppressor in the context of myeloid malignancies, but its role in lymphoma development has been less clear. In this issue of Cancer Discovery, Dominguez and colleagues report that TET2 function is critical for germinal center exit and plasma cell differentiation, and its deficiency can lead to B-cell lymphoma phenotypes.See related article by Dominguez et al., p. 1632.

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Comment on

  • TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis.
    Dominguez PM, Ghamlouch H, Rosikiewicz W, Kumar P, Béguelin W, Fontán L, Rivas MA, Pawlikowska P, Armand M, Mouly E, Torres-Martin M, Doane AS, Calvo Fernandez MT, Durant M, Della-Valle V, Teater M, Cimmino L, Droin N, Tadros S, Motanagh S, Shih AH, Rubin MA, Tam W, Aifantis I, Levine RL, Elemento O, Inghirami G, Green MR, Figueroa ME, Bernard OA, Aoufouchi S, Li S, Shaknovich R, Melnick AM. Dominguez PM, et al. Cancer Discov. 2018 Dec;8(12):1632-1653. doi: 10.1158/2159-8290.CD-18-0657. Epub 2018 Oct 1. Cancer Discov. 2018. PMID: 30274972 Free PMC article.

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