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Comment
. 2018 Dec 3;47(5):525-526.
doi: 10.1016/j.devcel.2018.11.027.

Chromosome Segregation Fidelity Integrates Information across Scales

Lila Neahring  1 , Sophie Dumont  2
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Chromosome Segregation Fidelity Integrates Information across Scales

Lila Neahring et al. Dev Cell. .
Free article

Abstract

The influence of tissue context is an emerging theme in cell biology. Recent work reveals that tissue architecture promotes chromosome segregation fidelity in epithelia, suggesting that aneuploidy in certain cancers may arise as a consequence of disrupted tissue architecture and highlighting the shortcomings of cell culture systems.

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