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Controlled Clinical Trial
. 2018 Dec 1;10(12):1851.
doi: 10.3390/nu10121851.

Lipidomic Response to Coffee Consumption

Alan Kuang  1 , Iris Erlund  2 , Christian Herder  3   4 , Johan A Westerhuis  5   6 , Jaakko Tuomilehto  7   8   9 , Marilyn C Cornelis  10
Affiliations
Controlled Clinical Trial

Lipidomic Response to Coffee Consumption

Alan Kuang et al. Nutrients. .

Abstract

Coffee is widely consumed and contains many bioactive compounds, any of which may impact pathways related to disease development. Our objective was to identify individual lipid changes in response to coffee drinking. We profiled the lipidome of fasting serum samples collected from a previously reported single blinded, three-stage clinical trial. Forty-seven habitual coffee consumers refrained from drinking coffee for 1 month, consumed 4 cups of coffee/day in the second month and 8 cups/day in the third month. Samples collected after each coffee stage were subject to quantitative lipidomic profiling using ion-mobility spectrometry⁻mass spectrometry. A total of 853 lipid species mapping to 14 lipid classes were included for univariate analysis. Three lysophosphatidylcholine (LPC) species including LPC (20:4), LPC (22:1) and LPC (22:2), significantly decreased after coffee intake (p < 0.05 and q < 0.05). An additional 72 species mapping to the LPC, free fatty acid, phosphatidylcholine, cholesteryl ester and triacylglycerol classes of lipids were nominally associated with coffee intake (p < 0.05 and q > 0.05); 58 of these decreased after coffee intake. In conclusion, coffee intake leads to lower levels of specific LPC species with potential impacts on glycerophospholipid metabolism more generally.

Keywords: biomarkers; caffeine; coffee; lipidomics; lipids; lysophosphatidylcholine; trial.

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Conflict of interest statement

The authors declare no conflict of interest

Figures

Figure 1
Figure 1
Lipid class (a) and LPC (b) composition response to coffee intake.
Figure 2
Figure 2
LPC concentration response to coffee intake. Shown are all nominally (a) to significant (a,b) LPCs that changed in response to coffee.
See this image and copyright information in PMC

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