Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Dec 2;10(12):683.
doi: 10.3390/v10120683.

Persistence and Sexual Transmission of Filoviruses

Brayden G Schindell  1 , Andrew L Webb  2 , Jason Kindrachuk  3
Affiliations
Review

Persistence and Sexual Transmission of Filoviruses

Brayden G Schindell et al. Viruses. .

Abstract

There is an increasing frequency of reports regarding the persistence of the Ebola virus (EBOV) in Ebola virus disease (EVD) survivors. During the 2014⁻2016 West African EVD epidemic, sporadic transmission events resulted in the initiation of new chains of human-to-human transmission. Multiple reports strongly suggest that these re-emergences were linked to persistent EBOV infections and included sexual transmission from EVD survivors. Asymptomatic infection and long-term viral persistence in EVD survivors could result in incidental introductions of the Ebola virus in new geographic regions and raise important national and local public health concerns. Alarmingly, although the persistence of filoviruses and their potential for sexual transmission have been documented since the emergence of such viruses in 1967, there is limited knowledge regarding the events that result in filovirus transmission to, and persistence within, the male reproductive tract. Asymptomatic infection and long-term viral persistence in male EVD survivors could lead to incidental transfer of EBOV to new geographic regions, thereby generating widespread outbreaks that constitute a significant threat to national and global public health. Here, we review filovirus testicular persistence and discuss the current state of knowledge regarding the rates of persistence in male survivors, and mechanisms underlying reproductive tract localization and sexual transmission.

Keywords: Ebola virus; blood-testis barrier; emerging virus; filovirus; outbreak; persistence; public health; sexual transmission; testis.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Localization of the blood-testis barrier within the male reproductive tract. (A) Localization of the seminiferous tubule within the testis; (B) Cell composition and structure of the blood-testis barrier and contribution of surrounding cells to the barrier function and homeostasis. Tissue and cell images were derived and/or modified from Servier Medical Art under a Creative Commons Attribution 3.0 Unported License.
See this image and copyright information in PMC

References

    1. Adams M., Carstens E.B. Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2014) Arch. Virol. 2014;159:2831–2841. doi: 10.1007/s00705-014-2114-3. - DOI - PubMed
    1. Kuhn J.H., Becker S., Ebihara H., Geisbert T.W., Jahrling P.B., Kawaoka Y., Netesov S.V., Nichol S.T., Peters C.J., Volchkov V.E., et al. Virus Taxonomy—Ninth Report of the International Committee on Taxonomy of Viruses. Elsevier/Academic Press; London, UK: 2011. Family filoviridae; pp. 665–671.
    1. Kuhn J.H. Filoviruses. A compendium of 40 years of epidemiological, clinical, and laboratory studies. Arch. Virol. Suppl. 2008;20:13–360. - PubMed
    1. Feldmann H., Sanchez A., Geisbert T.W. Filoviridae: Marburg and Ebola Viruses. In: Knipe D., Howley P.M., editors. Fields Virology. 6th ed. Wolters Kluwer Health/Lippincott Williams & Wilkins; Philadelphia, PA, USA: 2013.
    1. Goldstein T., Anthony S.J., Gbakima A., Bird B.H., Bangura J., Tremeau-Bravard A., Belaganahalli M.N., Wells H.L., Dhanota J.K., Liang E., et al. The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses. Nat. Microbiol. 2018;3:1084–1089. doi: 10.1038/s41564-018-0227-2. - DOI - PMC - PubMed

Publication types

MeSH terms