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Review
. 2018 Dec 3;10(12):1892.
doi: 10.3390/nu10121892.

Health Effects of Resveratrol: Results from Human Intervention Trials

Sonia L Ramírez-Garza  1   2 , Emily P Laveriano-Santos  3 , María Marhuenda-Muñoz  4   5 , Carolina E Storniolo  6   7 , Anna Tresserra-Rimbau  8 , Anna Vallverdú-Queralt  9   10 , Rosa M Lamuela-Raventós  11   12
Affiliations
Review

Health Effects of Resveratrol: Results from Human Intervention Trials

Sonia L Ramírez-Garza et al. Nutrients. .

Abstract

The effect of resveratrol (RV) intake has been reviewed in several studies performed in humans with different health status. The purpose of this review is to summarize the results of clinical trials of the last decade, in which RV was determined in biological samples such as human plasma, urine, and feces. The topics covered include RV bioavailability, pharmacokinetics, effects on cardiovascular diseases, cognitive diseases, cancer, type 2 diabetes (T2D), oxidative stress, and inflammation states. The overview of the recent research reveals a clear tendency to identify RV in plasma, showing that its supplementation is safe. Furthermore, RV bioavailability depends on several factors such as dose, associated food matrix, or time of ingestion. Notably, enterohepatic recirculation of RV has been observed, and RV is largely excreted in the urine within the first four hours after consumption. Much of the research on RV in the last 10 years has focused on its effects on pathologies related to oxidative stress, inflammatory biomarkers, T2D, cardiovascular diseases, and neurological diseases.

Keywords: antioxidant; bioavailability; metabolic diseases; obesity.

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Conflict of interest statement

R.M.L.-R. is receiving lecture fees from Cerveceros de España and lecture fees and travel support from Adventia. The other authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Bioavailability and pharmacokinetics. The image summarizes the results of different studies that identified resveratrol (RV) in urine and blood.
Figure 2
Figure 2
Health effects of resveratrol. A summary of the results of different studies reporting a positive effect of RV on health.
See this image and copyright information in PMC

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