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. 2019 Apr;93(4):372-375.
doi: 10.1016/j.diagmicrobio.2018.10.020. Epub 2018 Nov 10.

Killing activity of meropenem in combination with amikacin against VIM- or KPC-producing Enterobacteriaceae that are susceptible, intermediate, or resistant to amikacin

Brandon Kulengowski  1 , Justin A Clark  1 , David S Burgess  2
Affiliations

Killing activity of meropenem in combination with amikacin against VIM- or KPC-producing Enterobacteriaceae that are susceptible, intermediate, or resistant to amikacin

Brandon Kulengowski et al. Diagn Microbiol Infect Dis. 2019 Apr.

Abstract

Amikacin is administered with a carbapenem to treat serious infections caused by carbapenem-resistant Enterobacteriaceae (CRE). The varying degrees of activity of the individual agents correspond to differences in activity of the 2 in combination. Amikacin and meropenem are not bactericidal against amikacin-resistant CRE.

Keywords: Amikacin; Carbapenem-resistant Enterobacteriaceae; Meropenem; Polymyxin B; Time kill.

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