Platelet-rich Plasma for Skin Rejuvenation and Treatment of Actinic Elastosis in the Lower Eyelid Area

Abstract

Background Treatment of the lower eyelid region to rejuvenate the skin or treat actinic elastosis often proves difficult. Established treatment options, such as hyaluronic acid injections, botulinum toxin injections, microneedling, skin resurfacing (microdermabrasion, chemical peel (exfoliation), laser treatment), as well as blepharoplasties and autologous fat transfers, can be associated with significant risks and increased patient burden. Furthermore, they may not be effective for treating the signs of skin aging or actinic elastosis, including dark rings under the eyes, a lack of volume and cutis laxa. A minimally invasive treatment approach which visibly improves the above-mentioned conditions and which involves minimal risk and patient burden would be a desirable alternative. Materials & methods Twenty patients were treated a total of three times at monthly intervals with PRP (platelet-rich plasma). The patients were examined on the days of treatment and one month after the third injection. The PRP was obtained directly prior to treatment using the Arthrex ACP double syringe at the point of care. The injections (2 ml PRP per side) were administered laterally using 27 G 38 mm cannulas. Accurate photographic documentation and skin elasticity measurements using a cutometer were performed to objectify the subjective assessments from the patient and practitioner questionnaires. Results A progressive improvement in the esthetic outcome and a high level of patient satisfaction were determined. The cutometer measurements showed a statistically significant higher level of skin firmness (due to increased collagen production) and a statistically significant increase in skin elasticity (thanks to increased elastin production). Other than the anticipated visible swelling directly after the PRP injection, no other undesirable side effects or complications occurred. The typical burning sensation during the injection had not been reported. Conclusion The results indicate that a series of PRP injections in the lower eyelid region is a safe, efficient, virtually pain-free, simple and rapid treatment option for an area with otherwise limited treatment alternatives.

Keywords: acp; actinic elastosis; autologous conditioned plasma; dark circles; lower eyelid; personalized cell therapy; platelet-rich plasma; prp; skin rejuvenation; under-eye area.

Figure 1. Preparation of platelet-rich plasma (PRP).

Figure 2. Treatment results.

Female, 23 years, before the first (A), before the second (B), before the third (C), and four weeks after the third injection of platelet-rich plasma (PRP) (D).

Figure 3. Treatment results.

Female, 42 years, before the first (A), before the second (B), and before the third injection of platelet-rich plasma (PRP) (C).

Figure 4. Treatment results.

Female, 54 years, before the second (A), before the third (B), and four weeks after the third injection of platelet-rich plasma (PRP) (C).

Figure 5. Treatment results.

Male, 60 years, before the first (A), before the second (B), before the third (C), and four weeks after the third injection of platelet-rich plasma (PRP) (D).

Figure 6. Treatment results.

Female, 38 years, before the first (A), before the third (B) and four weeks after the third injection of platelet-rich plasma (PRP) (C).