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Comment
. 2018 Dec 4;28(6):801-802.
doi: 10.1016/j.cmet.2018.11.008.

Peeking under the Hood of Naive T Cells

Wei Xu  1 , Jonathan D Powell  2
Affiliations
Comment

Peeking under the Hood of Naive T Cells

Wei Xu et al. Cell Metab. .

Abstract

Signaling and transcriptional regulation of metabolic reprogramming upon T cell activation has been studied intensively. In this issue of Cell Metabolism, Ricciardi et al. (2018) show that translational regulation of key metabolic enzymes GLUT1 and ACC1 plays a novel role in human naive CD4 T cell activation and subset differentiation.

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Conflict of interest statement

DECLARATION OF INTERESTS

J.D.P. has equity in Dracen. Also in Sityrx, and Corvus (less than 5%). J.D.P. has consulted for Dracen, Sityrx, Corvus, Aeonian, Sigma, and Quadriga. J.D.P. has received sponsored research money from Abbvie, Quadriga, Dracen, BMS, and Bluebird. J.D.P. has patents licensed by Dracen.

Figures

Figure 1.
Figure 1.. Translational Regulation of Pre-accumulated Acc1 and Glut1 mRNAs in Naive T Cells Accounts for Rapid and Full Metabolic Reprogramming upon T Cell Activation
Human naive CD4+ T cells are poised to rapidly become activated by maintaining high levels of metabolic enzymes Acc1 and Glut1 mRNAs and translational machinery (left). Upon activation, translation repression is released and leads to rapid ACC1 and GLUT1 protein expression to fulfill fatty acid synthesis and glycolysis to support their function (right).
See this image and copyright information in PMC

Comment on

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