Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2018 Dec 4;28(6):803-805.
doi: 10.1016/j.cmet.2018.11.003.

Cancer-Induced Endoplasmic Reticulum Stress in T Cells Subverts Immunosurveillance

Alejandro López-Soto  1 , Guido Kroemer  2
Affiliations
Free article
Comment

Cancer-Induced Endoplasmic Reticulum Stress in T Cells Subverts Immunosurveillance

Alejandro López-Soto et al. Cell Metab. .
Free article

Abstract

Compelling evidence indicates that tumors may evade immunosurveillance by subverting the metabolism of immune cells. In a recent paper in Nature, Song et al. (2018) demonstrate that ovarian cancers activate IRE1α-XBP1 signaling within CD4+ T lymphocytes, thereby disrupting their bioenergetic function and contribution to anticancer immune responses.

PubMed Disclaimer

Comment on

  • IRE1α-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity.
    Song M, Sandoval TA, Chae CS, Chopra S, Tan C, Rutkowski MR, Raundhal M, Chaurio RA, Payne KK, Konrad C, Bettigole SE, Shin HR, Crowley MJP, Cerliani JP, Kossenkov AV, Motorykin I, Zhang S, Manfredi G, Zamarin D, Holcomb K, Rodriguez PC, Rabinovich GA, Conejo-Garcia JR, Glimcher LH, Cubillos-Ruiz JR. Song M, et al. Nature. 2018 Oct;562(7727):423-428. doi: 10.1038/s41586-018-0597-x. Epub 2018 Oct 10. Nature. 2018. PMID: 30305738 Free PMC article.

Publication types

LinkOut - more resources