Parasitic Behavior of Leukemic Cells in Systemic Host Metabolism

Julie Leca¹, Thorsten Berger¹, Tak Wah Mak²

Affiliations

¹ The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, ON, Canada.
² The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, ON, Canada; The University of Hong Kong, Hong Kong. Electronic address: tmak@uhnresearch.ca.

PMID: 30517895
DOI: 10.1016/j.cmet.2018.11.011

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Parasitic Behavior of Leukemic Cells in Systemic Host Metabolism

Julie Leca et al. Cell Metab. 2018.

Free article

. 2018 Dec 4;28(6):811-813.

doi: 10.1016/j.cmet.2018.11.011.

Authors

Julie Leca¹, Thorsten Berger¹, Tak Wah Mak²

Affiliations

¹ The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, ON, Canada.
² The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, ON, Canada; The University of Hong Kong, Hong Kong. Electronic address: tmak@uhnresearch.ca.

PMID: 30517895
DOI: 10.1016/j.cmet.2018.11.011

Abstract

Metabolic reprogramming is a hallmark of cancer cell metabolism. Recently, in Cancer Cell, Ye and colleagues (2018) reported that leukemic cells have the capacity to modulate glucose metabolism in multiple organs of their host, thereby increasing the glucose resources available for malignant cell growth.

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Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells.
Ye H, Adane B, Khan N, Alexeev E, Nusbacher N, Minhajuddin M, Stevens BM, Winters AC, Lin X, Ashton JM, Purev E, Xing L, Pollyea DA, Lozupone CA, Serkova NJ, Colgan SP, Jordan CT. Ye H, et al. Cancer Cell. 2018 Oct 8;34(4):659-673.e6. doi: 10.1016/j.ccell.2018.08.016. Epub 2018 Sep 27. Cancer Cell. 2018. PMID: 30270124 Free PMC article.

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Parasitic Behavior of Leukemic Cells in Systemic Host Metabolism

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Parasitic Behavior of Leukemic Cells in Systemic Host Metabolism

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Medical