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Comment
. 2018 Dec 4;28(6):813-815.
doi: 10.1016/j.cmet.2018.11.010.

Can We DECLARE a Victory against Cardio-Renal Disease in Diabetes?

Kim A Connelly  1 , Deepak L Bhatt  2 , Subodh Verma  3
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Comment

Can We DECLARE a Victory against Cardio-Renal Disease in Diabetes?

Kim A Connelly et al. Cell Metab. .
Free article

Abstract

Heart failure and renal disease remain significant complications in people with type 2 diabetes (T2D). Recent outcome studies with sodium-glucose cotransporter-2 (SGLT2) inhibitors have provided increasing insights, with the latest reporting trial DECLARE-TIMI 58 (Wiviott et al., 2018), pointing toward a role for these agents in the primary prevention of cardio-renal complications in T2D.

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  • Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes.
    Wiviott SD, Raz I, Bonaca MP, Mosenzon O, Kato ET, Cahn A, Silverman MG, Zelniker TA, Kuder JF, Murphy SA, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Ruff CT, Gause-Nilsson IAM, Fredriksson M, Johansson PA, Langkilde AM, Sabatine MS; DECLARE–TIMI 58 Investigators. Wiviott SD, et al. N Engl J Med. 2019 Jan 24;380(4):347-357. doi: 10.1056/NEJMoa1812389. Epub 2018 Nov 10. N Engl J Med. 2019. PMID: 30415602 Clinical Trial.

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