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Review
. 2018 Dec 4;15(12):2733.
doi: 10.3390/ijerph15122733.

Statins and Cardiovascular Disease Outcomes in Chronic Kidney Disease: Reaffirmation vs. Repudiation

Chamberlain I Obialo  1 , Elizabeth O Ofili  2 , Keith C Norris  3
Affiliations
Review

Statins and Cardiovascular Disease Outcomes in Chronic Kidney Disease: Reaffirmation vs. Repudiation

Chamberlain I Obialo et al. Int J Environ Res Public Health. .

Abstract

Cardiovascular disease (CVD) burden is several-fold higher in patients with chronic kidney disease (CKD). Although statins have been shown to provide significant CVD benefits in both the general population and patients with CKD, this has not translated into survival advantage in patients with advanced CKD or on dialysis. It has been reported that CVD risk continues to escalate as CKD progresses to end-stage kidney disease (ESKD); however, the CVD risk reduction by statins appears to decline as patients' progress from the early to later stages of CKD. Statins have also been associated with a higher incidence of stroke in ESKD patients. Thus, the CVD benefits of statins in ESKD remain questionable.

Keywords: Statins; cardiovascular disease; chronic kidney disease.

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Conflict of interest statement

The authors declare no conflict of interest.

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