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Randomized Controlled Trial
. 2019 Mar;36(3):453-459.
doi: 10.1007/s10815-018-1380-5. Epub 2018 Dec 5.

Transdermal versus oral estrogen: clinical outcomes in patients undergoing frozen-thawed single blastocyst transfer cycles without GnRHa suppression, a prospective randomized clinical trial

Semra Kahraman  1 , Caroline Pirkevi Çetinkaya  2 , Yucel Sahin  2 , Gokalp Oner  2
Affiliations
Randomized Controlled Trial

Transdermal versus oral estrogen: clinical outcomes in patients undergoing frozen-thawed single blastocyst transfer cycles without GnRHa suppression, a prospective randomized clinical trial

Semra Kahraman et al. J Assist Reprod Genet. 2019 Mar.

Abstract

Purpose: To conduct a non-inferiority study to compare the clinical outcomes of transdermal estrogen patch and oral estrogen in patients undergoing frozen-thawed single blastocyst transfer non-donor cycles without GnRHagonist (GnRHa) suppression.

Methods: A total of 317 women with irregular menses or anovulatory cycle undergoing frozen-thawed embryo transfer (FET) non-donor cycles without GnRHa suppression were involved in a prospective randomized clinical trial between May 2017 and October 2017. The trial was conducted in an ART and Reproductive Genetics Centre within a private hospital. The unit is designated as a teaching center by the Turkish Ministry of Health. Oral or transdermal estrogen was administered in patients undergoing frozen-thawed single blastocyst transfer. The outcomes of the study were the following: endometrial thickness on the day of progesterone administration, implantation rate, and clinical and viable ongoing pregnancy rates.

Results: Endometrial thickness and clinical outcomes of oral and transdermal estrogen administration were equally successful (p > 0.05).

Conclusion: No significant difference was found in endometrial thickness on the day of progesterone administration nor in clinical outcomes between transdermal estrogen and oral estrogen in patients undergoing frozen-thawed single blastocyst stage transfer cycles without GnRHa suppression.

Keywords: Cycle outcomes; Endometrial thickness; Oral estrogen; Transdermal estrogen.

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Conflict of interest statement

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. IRB approval was obtained from Istanbul Memorial Hospital prior to starting the study (Local IRB approval number: 2018–2).

Figures

Fig. 1
Fig. 1
CONSORT flowchart of the trial
See this image and copyright information in PMC

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