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. 2018 Dec 17;31(12):1290-1292.
doi: 10.1021/acs.chemrestox.8b00321. Epub 2018 Dec 6.

Key Characteristics Approach to Carcinogenic Hazard Identification

Kathryn Z Guyton  1 , Linda Rieswijk  2 , Amy Wang  3 , Weihsueh A Chiu  4 , Martyn T Smith  2
Affiliations

Key Characteristics Approach to Carcinogenic Hazard Identification

Kathryn Z Guyton et al. Chem Res Toxicol. .

Abstract

Evaluating carcinogenic mechanisms is a challenging part of hazard identification, as mechanistic data are both voluminous and diverse. An evaluation approach based on 10 key characteristics of human carcinogens provides a holistic and unbiased way to tackle this challenge.

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Figures

Figure 1.
Figure 1.
Key characteristics (KCs) of human carcinogens. Some human carcinogens such as ethylene oxide, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and etoposide (shown in blue in the center of the figure) exhibit a single or primary KC that has alone been influential in cancer hazard classifications. Other human carcinogens such as benzene, cigarette smoke, and asbestos (shown in black in the center of the figure) are recognized as exhibiting several KCs.
See this image and copyright information in PMC

References

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    1. National Academy of Sciences, Engineering and Medicine (2017) Using 21st Century Science to Improve Risk-Related Evaluations, The National Academies Press, Washington, DC. - PubMed
    1. Guyton KZ, Rusyn I, Chiu WA, Corpet DE, van den Berg M, Ross MK(2018) Application of the key characteristics of carcinogens in cancer hazard identification. Carcinogenesis 39 (4), 614–22,DOI: 10.1093/carcin/bgy031 - DOI - PMC - PubMed

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