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Review
. 2019 May;25(5):e145-e154.
doi: 10.1016/j.bbmt.2018.11.033. Epub 2018 Dec 3.

Non-Graft-versus-Host Disease Ocular Complications after Hematopoietic Cell Transplantation: Expert Review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society for Blood and Marrow Transplantation

Yoshihiro Inamoto  1 , Igor Petriček  2 , Linda Burns  3 , Saurabh Chhabra  4 , Zachariah DeFilipp  5 , Peiman Hematti  6 , Alicia Rovó  7 , Raquel Schears  8 , Ami Shah  9 , Vaibhav Agrawal  10 , Aisha Ahmed  11 , Ibrahim Ahmed  12 , Asim Ali  13 , Mahmoud Aljurf  14 , Hassan Alkhateeb  8 , Amer Beitinjaneh  15 , Neel Bhatt  16 , Dave Buchbinder  17 , Michael Byrne  18 , Natalie Callander  19 , Kristina Fahnehjelm  20 , Nosha Farhadfar  21 , Robert Peter Gale  22 , Siddhartha Ganguly  23 , Shahrukh Hashmi  14 , Gerhard C Hildebrandt  24 , Erich Horn  21 , Ann Jakubowski  25 , Rammurti T Kamble  26 , Jason Law  27 , Catherine Lee  28 , Sunita Nathan  29 , Olaf Penack  30 , Ravi Pingali  31 , Pinki Prasad  32 , Drazen Pulanic  33 , Seth Rotz  34 , Aditya Shreenivas  35 , Amir Steinberg  35 , Khalid Tabbara  36 , André Tichelli  37 , Baldeep Wirk  38 , Jean Yared  39 , Grzegorz W Basak  40 , Minoo Battiwalla  41 , Rafael Duarte  42 , Bipin N Savani  18 , Mary E D Flowers  43 , Bronwen E Shaw  16 , Nuria Valdés-Sanz  44
Affiliations
Review

Non-Graft-versus-Host Disease Ocular Complications after Hematopoietic Cell Transplantation: Expert Review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society for Blood and Marrow Transplantation

Yoshihiro Inamoto et al. Biol Blood Marrow Transplant. 2019 May.

Abstract

Non-graft-versus-host disease (GVHD) ocular complications are generally uncommon after hematopoietic cell transplantation (HCT) but can cause prolonged morbidity affecting activities of daily living and quality of life. Here we provide an expert review of non-GVHD ocular complications in a collaboration between transplantation physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. Complications discussed in this review include cataracts, glaucoma, ocular infections, ocular involvement with malignancy, ischemic microvascular retinopathy, central retinal vein occlusion, retinal hemorrhage, retinal detachment and ocular toxicities associated with medications. We summarize the incidence, risk factors, screening, prevention, and treatment of individual complications and generate evidence-based recommendations. Baseline ocular evaluation before HCT should be considered in all patients who undergo HCT. Follow-up evaluations should be considered according to clinical signs and symptoms and risk factors. Better preventive strategies and treatments remain to be investigated for individual ocular complications after HCT. Both transplantation physicians and ophthalmologists should be knowledgeable about non-GVHD ocular complications and provide comprehensive collaborative team care.

Keywords: Complication; Eye; Hematopoietic cell transplantation; Prevention; Review; Treatment.

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Conflict of interest statement

Conflict-of-interest statement: There are no conflicts of interest to discloset.

Figures

Figure 1.
Figure 1.
Structures of the eye
Figure 2.
Figure 2.
Ocular infections after allogeneic hematopoietic cell transplantation
See this image and copyright information in PMC

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