Cell-surface anchoring of proteins via glycosyl-phosphatidylinositol structures
- PMID: 3052274
- DOI: 10.1146/annurev.bi.57.070188.001441
Cell-surface anchoring of proteins via glycosyl-phosphatidylinositol structures
Abstract
A class of membrane molecules has been identified whose primary translation product includes a COOH-terminal protein sequence that signals attachment of a glycosyl-phosphatidylinositol anchor at a COOH-terminal residue that is newly formed by cleavage of the signaling sequence. This class includes a wide diversity of protein types from eukaryotes at many stages of evolution. The structures of the glycosyl-phosphatidylinositol anchors are being resolved, but their functions aside from membrane attachment and dynamics remain to be determined.
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