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Review
. 1988:57:285-320.
doi: 10.1146/annurev.bi.57.070188.001441.

Cell-surface anchoring of proteins via glycosyl-phosphatidylinositol structures

Affiliations
Review

Cell-surface anchoring of proteins via glycosyl-phosphatidylinositol structures

M A Ferguson et al. Annu Rev Biochem. 1988.

Abstract

A class of membrane molecules has been identified whose primary translation product includes a COOH-terminal protein sequence that signals attachment of a glycosyl-phosphatidylinositol anchor at a COOH-terminal residue that is newly formed by cleavage of the signaling sequence. This class includes a wide diversity of protein types from eukaryotes at many stages of evolution. The structures of the glycosyl-phosphatidylinositol anchors are being resolved, but their functions aside from membrane attachment and dynamics remain to be determined.

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