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. 1978 Feb;37(1):42-7.
doi: 10.1136/ard.37.1.42.

Rheumatic disorders in primary biliary cirrhosis

A K Clarke, R M Galbraith, E B Hamilton, R Williams

Rheumatic disorders in primary biliary cirrhosis

A K Clarke et al. Ann Rheum Dis. 1978 Feb.

Abstract

Eighty-three patients with primary biliary cirrhosis were investigated to determine the prevalence of rheumatic disorders. 14 had scleroderma, which tended to be mild but in several patients produced severe systemic manifestations. The CRST syndrome (calcinosis, Raynaud's phenomenon, sclerodactyly, telangiectasia) was only identified twice. There was an increased incidence of HLA A1+B8 in those patients with scleroderma. As well as those with scleroderma, 4 patients had a destructive arthropathy resembling avascular necrosis. 4 patients had an inflammatory arthritis, without specific features, but the frequency was no greater than might be expected in the general population.

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