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Review
. 2019 Feb;44(2):281-296.
doi: 10.1007/s11064-018-2695-4. Epub 2018 Dec 6.

Molecular Mechanisms of Early and Late LTP

Saltuk Bugra Baltaci  1 , Rasim Mogulkoc  1 , Abdulkerim Kasim Baltaci  2
Affiliations
Review

Molecular Mechanisms of Early and Late LTP

Saltuk Bugra Baltaci et al. Neurochem Res. 2019 Feb.

Abstract

LTP is the most intensively studied cellular model of the memory and generally divided at least two distinct phases as early and late. E-LTP requires activation of CaMKII that initiates biochemical events and trafficking of proteins, which eventually potentiate synaptic transmission, and is independent of de novo protein synthesis. In contrast, L-LTP requires gene expression and local protein synthesis regulated via TrkB receptor- and functional prions CPEB2-3-mediated translation. Maintenance of LTP for longer periods depends on constitutively active PKMζ. Throughout this review, current knowledge about early and late phases of LTP will be reviewed.

Keywords: Cpeb; Functional prions; Learning and memory; Ltp; Pkm zeta; Synaptic plasticity.

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References

    1. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3239-44 - PubMed
    1. Science. 1999 Jun 11;284(5421):1805-11 - PubMed
    1. Science. 1999 Jun 11;284(5421):1811-6 - PubMed
    1. Nat Neurosci. 1999 Jul;2(7):625-33 - PubMed
    1. Semin Cell Dev Biol. 1999 Apr;10(2):205-14 - PubMed

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