Influence of size and surface capping on photoluminescence and cytotoxicity of gold nanoparticles
- PMID: 30524191
- PMCID: PMC6244783
- DOI: 10.1007/s11051-018-4406-0
Influence of size and surface capping on photoluminescence and cytotoxicity of gold nanoparticles
Abstract
Hydrophilic and homogeneous sub-10 nm blue light-emitting gold nanoparticles (NPs) functionalized with different capping agents have been prepared by simple chemical routes. Structure, average, size, and surface characteristics of these NPs have been widely studied, and the stability of colloidal NP solutions at different pH values has been evaluated. Au NPs show blue PL emission, particularly in the GSH capped NPs, in which the thiol-metal core transference transitions considerably enhance the fluorescent emission. The influence of capping agent and NP size on cytotoxicity and on the fluorescent emission are analyzed and discussed in order to obtain Au NPs with suitable features for biomedical applications. Cytotoxicity of different types of gold NPs has been determined using NPs at high concentrations in both tumor cell lines and primary cells. All NPs used show high biocompatibility with low cytotoxicity even at high concentration, while Au-GSH NPs decrease viability and proliferation of both a tumor cell line and primary lymphocytes.
Keywords: Agent; Capping; Cell viability; Cytotoxicity; GSH; Gold nanoparticles; Photoluminescence; Proliferation; Semiconfocal microscopy.
Conflict of interest statement
Compliance with ethical standardsThe authors declare that they have no conflict of interest.
Figures










References
-
- Anand K, Singh T, Madhumitha G, Phulukdaree A, Gengan RM, Chuturgoon AA. Biosynthesis and computational analysis of amine-ended dual thiol ligand functionalized gold nanoparticles for conventional spectroscopy detection of melamine. J Photochem Photobiol B. 2017;169:75–82. doi: 10.1016/j.jphotobiol.2017.02.019. - DOI - PubMed
LinkOut - more resources
Full Text Sources
Miscellaneous