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. 1988 Sep 30;155(3):1244-7.
doi: 10.1016/s0006-291x(88)81273-7.

Endothelin inhibits renin release from isolated rat glomeruli

H Rakugi  1 , M Nakamaru, H Saito, J Higaki, T Ogihara
Affiliations

Endothelin inhibits renin release from isolated rat glomeruli

H Rakugi et al. Biochem Biophys Res Commun. .

Abstract

The effect of endothelin on renin release from isolated rat glomeruli was examined. Endothelin inhibited basal renin release in a dose-dependent manner with an IC50 of 1.0 x 10(-9) M. Endothelin also inhibited renin release stimulated by isoproterenol (10(-5) M). Nifedipine (10(-5) M), a calcium channel blocker, induced an increase in renin release. Endothelin did not affect this nifedipine-induced renin release. These results suggest that endothelin inhibits renin release via a calcium entry mechanism and increases intracellular calcium.

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