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Review
. 2018 Aug 24:9:32-37.
doi: 10.1016/j.reth.2018.08.001. eCollection 2018 Dec.

Mesenchymal stromal cells as a potential therapeutic for neurological disorders

Takeo Mukai  1   2 , Arinobu Tojo  1   2 , Tokiko Nagamura-Inoue  2
Affiliations
Review

Mesenchymal stromal cells as a potential therapeutic for neurological disorders

Takeo Mukai et al. Regen Ther. .

Abstract

Several studies have reported that mesenchymal stromal/stem cells (MSCs) restore neurological damage through their secretion of paracrine factors or their differentiation to neuronal cells. Based on these studies, many clinical trials have been conducted using MSCs for neurological disorders, and their safety and efficacy have been reported. In this review, we provide a brief introduction to MSCs, especially umbilical cord derived-MSCs (UC-MSCs), in terms of characteristics, isolation, and cryopreservation, and discuss the recent progress in regenerative therapies using MSCs for various neurological disorders.

Keywords: Cerebral palsy; Mesenchymal stromal cell; Neurological disorders; Neurotrophic factor; Umbilical cord.

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Figures

Fig. 1
Fig. 1
Characteristics of MSCs.
See this image and copyright information in PMC

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