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Case Reports
. 2018 Dec 7;18(1):312.
doi: 10.1186/s12886-018-0968-y.

Multiple evanescent white dot syndrome following rabies vaccination: a case report

Jia-Song Yang  1 , Chun-Li Chen  2   3 , Yu-Zhang Hu  4 , Rui Zeng  5
Affiliations
Case Reports

Multiple evanescent white dot syndrome following rabies vaccination: a case report

Jia-Song Yang et al. BMC Ophthalmol. .

Abstract

Background: To report a case of multiple evanescent white dot syndrome (MEWDS) following simultaneous rabies vaccination.

Case presentation: Review of the clinical, laboratory, photographic, optical coherence tomographic (OCT), fundus autofluorescent, angiographic, electrophysiologic, and perimetric records of a patient suffering from MEWDS.

Results: A healthy 33-year-old Chinese female suffering from rapidly progressive visual loss of her left eye associated with photopsia and a para-central scotoma, seven days after receiving simultaneous rabies vaccination. Both anterior segments and fundus examination were unremarkable. The findings on OCT, electrophysiology, and perimetry were pathognomonic for MEWDS.

Conclusions: The clinical presentation and the benign course were consistent with the diagnosis of MEWDS. No other events could be identified as a cause, other than the rabies vaccination. This case may suggest an autoimmune basis for MEWDS in predisposed patients.

Keywords: Multiple evanescent white dot syndrome; Rabies vaccine; Vaccination/adverse events.

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Conflict of interest statement

Ethics approval and consent to participate

Ethical approval was not required as this manuscript presents a case study. It was performed in accordance with the tenets of the Declaration of Helsinki.

Consent for publication

Written informed consent was obtained from the patient for publication of this case report and any accompanying images.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
a. Octopus visual field showed an enlarged blind spot and decreased sensitivity superiorly and nasally. b. 2 months later, the visual field resolved
Fig. 2
Fig. 2
FFA showed right eye the normal appearances in arteriovenous phase (a) and late phase (b), and early choroidal background hyperfluorescence (c) and mild diffuse leakage of fluorescein was noted in the late phase (d) of the left eye
Fig. 3
Fig. 3
a. Optical coherence tomograpy scan showed the interrupted ellipsoid zone of the left eye at the initial visiting time. b. The ellipsoid zone partially resolved 2 months later
Fig. 4
Fig. 4
a. Fundus AF demonstrated multiple ill-defined spots of markedly increased AF in the posterior pole. b. 2 months later, the hyerfluoscent spots decreased on AF
Fig. 5
Fig. 5
a & b. Three years later, the fundus was completely restored to normal both on fundus phtograph and OCT
See this image and copyright information in PMC

References

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