Restoring Fertility with Human Induced Pluripotent Stem Cells: Are We There Yet?

Joanna J Gell¹, Amander T Clark²

Affiliations

¹ Department of Pediatrics, Division of Hematology-Oncology, Los Angeles, CA, USA; David Geffen School of Medicine, Los Angeles, CA, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA, USA.
² Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, CA, USA; Molecular Biology Institute, University of California, Los Angeles, CA, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA, USA. Electronic address: clarka@ucla.edu.

PMID: 30526878
DOI: 10.1016/j.stem.2018.11.003

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Restoring Fertility with Human Induced Pluripotent Stem Cells: Are We There Yet?

Joanna J Gell et al. Cell Stem Cell. 2018.

Free article

. 2018 Dec 6;23(6):777-779.

doi: 10.1016/j.stem.2018.11.003.

Authors

Joanna J Gell¹, Amander T Clark²

Affiliations

¹ Department of Pediatrics, Division of Hematology-Oncology, Los Angeles, CA, USA; David Geffen School of Medicine, Los Angeles, CA, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA, USA.
² Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, CA, USA; Molecular Biology Institute, University of California, Los Angeles, CA, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA, USA. Electronic address: clarka@ucla.edu.

PMID: 30526878
DOI: 10.1016/j.stem.2018.11.003

Abstract

Overcoming infertility with assisted reproduction requires high-quality eggs and sperm. For those young women who no longer make functional eggs, the hope of conceiving a biological child just got one step closer with a recent publication in Science from Yamashiro et al. (2018).

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Generation of human oogonia from induced pluripotent stem cells in vitro.
Yamashiro C, Sasaki K, Yabuta Y, Kojima Y, Nakamura T, Okamoto I, Yokobayashi S, Murase Y, Ishikura Y, Shirane K, Sasaki H, Yamamoto T, Saitou M. Yamashiro C, et al. Science. 2018 Oct 19;362(6412):356-360. doi: 10.1126/science.aat1674. Epub 2018 Sep 20. Science. 2018. PMID: 30237246

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Restoring Fertility with Human Induced Pluripotent Stem Cells: Are We There Yet?

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Restoring Fertility with Human Induced Pluripotent Stem Cells: Are We There Yet?

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Abstract

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Medical