Does Adult Neurogenesis Persist in the Human Hippocampus?

Mercedes F Paredes¹, Shawn F Sorrells², Arantxa Cebrian-Silla³, Kadellyn Sandoval¹, Dashi Qi⁴, Kevin W Kelley⁵, David James⁵, Simone Mayer², Julia Chang⁶, Kurtis I Auguste⁷, Edward F Chang⁷, Antonio J Gutierrez Martin⁸, Arnold R Kriegstein¹, Gary W Mathern⁹, Michael C Oldham¹, Eric J Huang¹⁰, Jose Manuel Garcia-Verdugo³, Zhengang Yang⁴, Arturo Alvarez-Buylla¹¹

Affiliations

¹ Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA.
² Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
³ Laboratorio de Neurobiología Comparada, Instituto Cavanilles, Universidad de Valencia, CIBERNED, Valencia 46980, Spain.
⁴ State Key Laboratory of Medical Neurobiology and Institutes of Brain Science, Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
⁵ Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA.
⁶ David Geffen School of Medicine, Department of Neurosurgery, Intellectual Development and Disabilities Research Center, University of California, Los Angeles, Los Angeles, CA, USA.
⁷ Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
⁸ Unidad de Cirugía de la Epilepsia, Hospital Universitario La Fe, Valencia 46026, Spain.
⁹ Departments of Neurosurgery and Psychiatry & BioBehavioral Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
¹⁰ Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
¹¹ Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: abuylla@stemcell.ucsf.edu.

PMID: 30526879
PMCID: PMC6800191
DOI: 10.1016/j.stem.2018.11.006

Comment

Does Adult Neurogenesis Persist in the Human Hippocampus?

Mercedes F Paredes et al. Cell Stem Cell. 2018.

. 2018 Dec 6;23(6):780-781.

doi: 10.1016/j.stem.2018.11.006.

Authors

Affiliations

¹ Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA.
² Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
³ Laboratorio de Neurobiología Comparada, Instituto Cavanilles, Universidad de Valencia, CIBERNED, Valencia 46980, Spain.
⁴ State Key Laboratory of Medical Neurobiology and Institutes of Brain Science, Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
⁵ Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA.
⁶ David Geffen School of Medicine, Department of Neurosurgery, Intellectual Development and Disabilities Research Center, University of California, Los Angeles, Los Angeles, CA, USA.
⁷ Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
⁸ Unidad de Cirugía de la Epilepsia, Hospital Universitario La Fe, Valencia 46026, Spain.
⁹ Departments of Neurosurgery and Psychiatry & BioBehavioral Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
¹⁰ Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
¹¹ Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: abuylla@stemcell.ucsf.edu.

PMID: 30526879
PMCID: PMC6800191
DOI: 10.1016/j.stem.2018.11.006

No abstract available

PubMed Disclaimer

Comment in

Considerations for Assessing the Extent of Hippocampal Neurogenesis in the Adult and Aging Human Brain.
Tartt AN, Fulmore CA, Liu Y, Rosoklija GB, Dwork AJ, Arango V, Hen R, Mann JJ, Boldrini M. Tartt AN, et al. Cell Stem Cell. 2018 Dec 6;23(6):782-783. doi: 10.1016/j.stem.2018.10.025. Cell Stem Cell. 2018. PMID: 30526880 Free PMC article. No abstract available.

Comment on

Human Hippocampal Neurogenesis Persists throughout Aging.
Boldrini M, Fulmore CA, Tartt AN, Simeon LR, Pavlova I, Poposka V, Rosoklija GB, Stankov A, Arango V, Dwork AJ, Hen R, Mann JJ. Boldrini M, et al. Cell Stem Cell. 2018 Apr 5;22(4):589-599.e5. doi: 10.1016/j.stem.2018.03.015. Cell Stem Cell. 2018. PMID: 29625071 Free PMC article.
Human Adult Neurogenesis: Evidence and Remaining Questions.
Kempermann G, Gage FH, Aigner L, Song H, Curtis MA, Thuret S, Kuhn HG, Jessberger S, Frankland PW, Cameron HA, Gould E, Hen R, Abrous DN, Toni N, Schinder AF, Zhao X, Lucassen PJ, Frisén J. Kempermann G, et al. Cell Stem Cell. 2018 Jul 5;23(1):25-30. doi: 10.1016/j.stem.2018.04.004. Epub 2018 Apr 19. Cell Stem Cell. 2018. PMID: 29681514 Free PMC article. Review.

References

1. Boldrini M, Fulmore CA, Tartt AN, Simeon LR, Pavlova I, Poposka V, Rosoklija GB, Stankov A, Arango V, Dwork AJ, et al. (2018). Human hippocampal neurogenesis persists throughout aging. Cell Stem Cell 22, 589–599.e5. - PMC - PubMed
1. Cipriani S, Ferrer I, Aronica E, Kovacs GG, Verney C, Nardelli J, Khung S, Delezoide AL, Milenkovic I, Rasika S, et al. (2018). Hippocampal radial glial subtypes and their neurogenic potential in human fetuses and healthy and Alzheimer’s disease adults. Cereb. Cortex 28, 2458–2478. - PubMed
1. Dennis CV, Suh LS, Rodriguez ML, Kril JJ, and Sutherland GT (2016). Human adult neurogenesis across the ages: an immunohistochemical study. Neuropathol. Appl. Neurobiol 42, 621–638. - PMC - PubMed
1. Kempermann G, Gage FH, Aigner L, Song H, Curtis MA, Thuret S, Kuhn HG, Jessberger S, Frankland PW, Cameron HA, et al. (2018). Human adult neurogenesis: evidence and remaining questions. Cell Stem Cell 23, 25–30. - PMC - PubMed
1. Knoth R, Singec I, Ditter M, Pantazis G, Capetian P, Meyer RP, Horvat V, Volk B, and Kempermann G. (2010). Murine features of neurogenesis in the human hippocampus across the lifespan from 0 to 100 years. PLoS ONE 5, e8809. - PMC - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions

Grants and funding

R01 NS028478/NS/NINDS NIH HHS/United States

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Does Adult Neurogenesis Persist in the Human Hippocampus?

Affiliations

Does Adult Neurogenesis Persist in the Human Hippocampus?

Authors

Affiliations

Comment in

Comment on

References

Publication types

MeSH terms

Grants and funding