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Review
. 2019 Jan;40(1):4-7.
doi: 10.1016/j.tips.2018.10.008. Epub 2018 Dec 6.

MDSC; the Most Important Cell You Have Never Heard Of

R J Tesi  1
Affiliations
Review

MDSC; the Most Important Cell You Have Never Heard Of

R J Tesi. Trends Pharmacol Sci. 2019 Jan.

Abstract

The myeloid-derived suppressor cell (MDSC) is the 'queen bee' of the tumor microenvironment. MDSCs protect the cancer from the patient's immune system, make the tumor resistant to immunotherapy, and allow the tumor to thrive while the patient withers away. Eliminating MDSCs should improve response rates to cancer therapy and patient survival.

Keywords: cancer therapy; myeloid-derived suppressor cell; tumor microenvironment.

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