Thesaurus for off-label indications for systemic antifungal agents

Abstract

Objectives: Following the removal of temporary treatment protocol procedures, we developed a thesaurus for off-label indications for systemic antifungals at our facility to update clinical practices and to control off-label prescriptions.

Materials and methods: Clinical practice guidelines and literature data were analyzed. This work was part of an antifungal stewardship program.

Results: Off-label wording (prophylaxis, preemptive, empirical, curative) and corresponding antifungals and references were validated by the multidisciplinary group for antifungal agents under the aegis of the Commission for the use of drugs and sterile medical devices and of the anti-infective committee.

Conclusion: Considering the complexity of invasive fungal infection management, this thesaurus needs to be shared and used as a helping tool to review off-label situations.

Keywords: Antifongiques; Antifungal stewardship; Antifungals; Bon usage des antifongiques.