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. 2019 Mar:206:13-19.
doi: 10.1016/j.jpeds.2018.11.026. Epub 2018 Dec 6.

Cerebrospinal Fluid Shunt Infection: Emerging Paradigms in Pathogenesis that Affect Prevention and Treatment

Tamara D Simon  1 , Joshua K Schaffzin  2 , Charles B Stevenson  3 , Kathryn Willebrand  4 , Matthew Parsek  4 , Lucas R Hoffman  5
Affiliations

Cerebrospinal Fluid Shunt Infection: Emerging Paradigms in Pathogenesis that Affect Prevention and Treatment

Tamara D Simon et al. J Pediatr. 2019 Mar.
No abstract available

Keywords: cerebrospinal fluid; infection; prevention; shunt; treatment.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1.
Figure 1.
A framework for understanding patient and procedural risk factors for development of a first CSF shunt infection. Shaded boxes indicate possible surgeries; CSF infection can occur without an interval revision procedure.
Figure 2.
Figure 2.
Microbiota in the CSF of a child with CSF shunt infection. Shown are bacterial taxa identified by 16S bacterial tag-encoded FLX-Titanium amplicon pyrosequencing (bTEFAP) at the time of an initial CSF sample, presented as a proportion of all sequence detections in the sample representing bacteria for which detection comprised 1% or more of the total. The sole bacterium that was identified in conventional culture (S. epidermidis) is designated with an asterisk. Negative controls of donated CSF that underwent concurrent DNA extraction revealed no detection by bTEFAP analysis (data not shown).
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