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Review
. 2019 Mar;28(2):140-147.
doi: 10.1097/MNH.0000000000000480.

Differences in national and international guidelines regarding use of kidney stone formers as living kidney donors

Vasishta S Tatapudi  1 , David S Goldfarb  2
Affiliations
Review

Differences in national and international guidelines regarding use of kidney stone formers as living kidney donors

Vasishta S Tatapudi et al. Curr Opin Nephrol Hypertens. 2019 Mar.

Abstract

Purpose of review: Traditionally, nephrolithiasis was considered a relative contraindication to kidney donation because of a risk of recurrent stones in donors and adverse stone-related outcomes in recipients. However, the scarcity of organs has driven the transplant community to re-examine and broaden selection criteria for living donors with stones. In this review, we summarize and contrast the guidelines published by various prominent national and international societies on this topic.

Recent findings: Although recent iterations of living donor guidelines are less stringent with respect to nephrolithiasis than those published in the 1990s, there is little consensus among national and international transplant society guidelines regarding selection criteria for potential kidney donors with nephrolithiasis.

Summary: The lack of evidence-based guidelines deters transplant centers from implementing selection criteria to accept donors with nephrolithiasis and discourages studies of outcomes in donors with nephrolithiasis and their recipients. In addition to drawing attention to the disparities in prevailing guidelines, we put forth several questions that must be answered before generalizable criteria for selection of donor with nephrolithiasis can be developed.

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Conflict of interest statement

Conflicts of interest: Tatapudi: None. Goldfarb: honoraria, Retrophin; consultant: Retrophin, Allena, Alnylam

Figures

Figure 1:
Figure 1:. Amsterdam Forum on the Care of the Live Kidney Donor - criteria for living kidney donors with nephrolithiasis (13).
*Cystine stones, struvite stones, stones in the setting of inflammatory bowel disease, recurrent stones while on appropriate treatment, stones associated with inherited or systemic disorders such as primary or enteric hyperoxaluria, distal renal tubular acidosis, and sarcoid.
See this image and copyright information in PMC

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