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Comment
. 2018 Dec 11;16(12):e3000067.
doi: 10.1371/journal.pbio.3000067. eCollection 2018 Dec.

Far away from the lamppost

Tudor I Oprea  1 , Lily Jan  2 , Gary L Johnson  3 , Bryan L Roth  4 , Avi Ma'ayan  5 , Stephan Schürer  6 , Brian K Shoichet  7 , Larry A Sklar  8 , Michael T McManus  9
Affiliations
Comment

Far away from the lamppost

Tudor I Oprea et al. PLoS Biol. .

Abstract

This Formal Comment responds to a recent Meta-Research Article by identifying initiatives that are already in place for funding risky exploratory research that illuminate mysteries of the dark genome.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Comment in

  • Reply to "Far away from the lamppost".
    Stoeger T, Gerlach M, Morimoto RI, Amaral LAN. Stoeger T, et al. PLoS Biol. 2018 Dec 11;16(12):e3000075. doi: 10.1371/journal.pbio.3000075. eCollection 2018 Dec. PLoS Biol. 2018. PMID: 30532190 Free PMC article.

Comment on

References

    1. Stoeger T, Gerlach M, Morimoto RI, Nunes Amaral LA. Large-scale investigation of the reasons why potentially important genes are ignored. PLoS Biol. 2018;16(9):e2006643 10.1371/journal.pbio.2006643 (2018). - DOI - PMC - PubMed
    1. Oprea T. I. et al. Unexplored therapeutic opportunities in the human genome. Nat Rev Drug Discov 17, 377, 10.1038/nrd.2018.52 (2018). - DOI - PubMed
    1. Rodgers G. et al. Glimmers in illuminating the druggable genome. Nat Rev Drug Discov 17, 301–302, 10.1038/nrd.2017.252 (2018). - DOI - PMC - PubMed
    1. Munoz-Fuentes V. et al. The International Mouse Phenotyping Consortium (IMPC): a functional catalogue of the mammalian genome that informs conservation. Conserv Genet 19, 995–1005, 10.1007/s10592-018-1072-9 (2018). - DOI - PMC - PubMed
    1. Meehan T. F. et al. Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium. Nat Genet 49, 1231–1238, 10.1038/ng.3901 (2017). - DOI - PMC - PubMed

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