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. 2018 Nov;11(10):1385-1396.
doi: 10.14202/vetworld.2018.1385-1396. Epub 2018 Oct 8.

Demographic aspects of human hydatidosis in Iranian general population based on serology: A systematic review and meta-analysis

Shirzad Gholami  1 , Asal Tanzifi  1   2 , Mehdi Sharif  1 , Ahmad Daryani  1 , Mohammad-Taghi Rahimi  3 , Siavash Mirshafiee  4 , Shahabeddin Sarvi  1
Affiliations

Demographic aspects of human hydatidosis in Iranian general population based on serology: A systematic review and meta-analysis

Shirzad Gholami et al. Vet World. 2018 Nov.

Abstract

Aim: Human cystic echinococcosis (CE), caused by the larval stage of Echinococcus granulosus cestodes, is a globally distributed chronic disease that is an important socioeconomic and public health problem in humans and livestock in developing countries, including Iran. The aim of this study was to determine the overall seroprevalence of hydatid infection in the general population of Iran.

Materials and methods: This systematic review began by searching electronic databases in English (PubMed, Science Direct, Scopus, and Google Scholar) and Persian (Magiran, Scientific Information Database, Iran Medex, and Iran Doc).

Results: Our search resulted in a total of 40 reports published from 1995 to 2015. Of 49,460 individuals surveyed, 3090 cases of hydatidosis were reported. Community-based studies showed that the seroprevalence of CE in the Iranian general population was 6.0% (95% confidence interval: 5.0-7.0%). The age group with the highest CE seroprevalence was 20-40 years, and the lowest one was in the under 20 year's group. The seroprevalence of hydatidosis in males was significantly higher than that in females. In addition, the intended rate was significantly higher in rural regions than in urban areas.

Conclusion: Management program for developing more efficient diagnostic tests should be established. Further, cost-effective preventive approaches, including relevant research, should be considered. Finally, hydatid cyst control programs that are important for interrupting the transmission of human CE should be improved.

Keywords: Iran; cystic echinococcosis; diagnosis; general population; hydatidosis; seroprevalence.

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Figures

Figure-1
Figure-1
Flowchart describing the study design process.
Figure-2
Figure-2
Forest plot for the prevalence of serology hydatidosis in general population in Iran.
Figure-3
Figure-3
Forest plot for distribution seroprevalence of hydatidosis in male and female groups in Iran.
Figure-4
Figure-4
Forest plot for distribution seroprevalence of hydatidosis in urban and rural groups in Iran.
Figure-5
Figure-5
Forest plot for distribution hydatid cyst serology in terms of lab methods in Iran.
Figure-6
Figure-6
Distribution of Iranian cystic echinococcosis seroprevalences in different provinces.
Figure-7
Figure-7
Begg’s funnel plot for assessing publication bias in the seroprevalence analysis of hydatidosis.
See this image and copyright information in PMC

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