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. 2019 Feb 6;141(5):1798-1806.
doi: 10.1021/jacs.8b09756. Epub 2018 Dec 11.

Chemical Interventions for the Opioid Crisis: Key Advances and Remaining Challenges

Margaret E Olson  1 , Lisa M Eubanks  1 , Kim D Janda  1
Affiliations

Chemical Interventions for the Opioid Crisis: Key Advances and Remaining Challenges

Margaret E Olson et al. J Am Chem Soc. .

Abstract

The present United States opioid crisis requires urgent and innovative scientific intervention. This perspective highlights a role for the chemical sciences by expounding upon three key research areas identified as priorities by the National Institute on Drug Abuse (NIDA). Specifically, important advances in chemical interventions for overdose reversal, strategies for opioid use disorder (OUD) treatment, including immunopharmacotherapies, and next-generation alternatives for pain management will be discussed. Ultimately, progress made will be presented in light of remaining challenges for the field.

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Conflict of interest statement

The authors declare no competing financial interest.

Figures

Figure 1.
Figure 1.
Timeline of defining events in the opioid crisis.
Figure 2.
Figure 2.
Investigatory AMPAkine and 5-HT1A modulators for opioid-induced respiratory depression (OIRD) reversal.
Figure 3.
Figure 3.
Next-generation, non-MOR modulating treatments for OUD.
Figure 4.
Figure 4.
(A) Structure of the first opioid immunopharmacotherapy, 6-hemisuccinylmorphine-BSA; (B) metabolic pathway of heroin, including half-lives in humans.
Figure 5.
Figure 5.
Structures of heroin immunopharmacotherapies.
Figure 6.
Figure 6.
Structures of non-heroin opioid immunopharmacotherapies.
Figure 7.
Figure 7.
New pharmacotherapeutic strategies in pain management.
See this image and copyright information in PMC

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